$ 59 / 10mg
999 in stock (can be backordered)
KPV (Lys-Pro-Val) is a naturally derived tripeptide fragment from alpha-melanocyte-stimulating hormone (α-MSH) studied in preclinical models for its potent anti-inflammatory and tissue-repair properties. Unlike full-length α-MSH, KPV peptide retains the anti-inflammatory signaling while lacking melanocortin-receptor-mediated pigmentation effects — making it a focused tool for inflammation and mucosal-healing research.
KPV peptide modulates NF-κB signaling, a master regulator of inflammatory gene expression. In cell-culture and colitis models, KPV has been shown to suppress pro-inflammatory cytokine production (TNF-α, IL-6, IL-1β) and promote mucosal barrier integrity. Research suggests it can be transported across intestinal epithelial cells, enabling direct interaction with immune cells in the gut-associated lymphoid tissue (GALT).
Researchers studying gut health and tissue repair often pair KPV with BPC-157, which targets gastric-peptide-based healing pathways, and LL-37, which provides antimicrobial defense alongside tissue-repair signaling. For broader regenerative studies, the BPC-157 + TB-500 combo offers a multi-pathway approach.
Each vial contains KPV peptide manufactured in the USA under ISO-certified conditions. Verified to ≥99% purity by HPLC analysis, with endotoxin screening below 0.1 EU/mg. Certificate of Analysis (COA) available upon request. For laboratory research use only.
Lyophilized KPV peptide should be stored at -20°C upon receipt to preserve its anti-inflammatory activity and structural stability. Keep vials sealed and protected from light, heat, and moisture during storage. For reconstitution, use bacteriostatic water (0.9% benzyl alcohol) and allow the lyophilized powder to dissolve gently without vortexing. Once reconstituted, store the peptide solution at 2–8°C and use within 28 days to ensure consistent bioactivity. As a small tripeptide, KPV is particularly sensitive to degradation from repeated freeze-thaw cycles, so aliquoting into single-use volumes is recommended. Handle under standard aseptic laboratory conditions. For research use only.
KPV (Lys-Pro-Val) was first identified as the C-terminal tripeptide fragment of α-MSH responsible for the hormone’s anti-inflammatory signaling, independent of its melanocortin receptor-mediated pigmentation effects. Early characterization work was conducted at institutions including the University of Catania in Italy and Tulane University, where researchers demonstrated KPV’s ability to inhibit NF-κB activation and suppress pro-inflammatory cytokine production. Since those foundational studies, KPV has appeared in over 80 peer-reviewed publications examining its roles in colitis models, mucosal barrier function, and skin-inflammation research. Key contributions from groups at the University of Lille and Emory University have further established its transepithelial transport properties and direct interaction with gut-associated lymphoid tissue. KPV remains a widely referenced tripeptide in inflammatory bowel disease and mucosal-healing research literature. All citations pertain to preclinical and laboratory research only.
KPV is a C-terminal tripeptide fragment of α-MSH that retains the anti-inflammatory NF-κB modulation activity but lacks the structural elements required for melanocortin receptor binding and melanogenesis activation. This allows researchers to study isolated anti-inflammatory effects without confounding pigmentation signals from the parent hormone. This product is supplied for laboratory research use only.
KPV is manufactured in the USA under ISO-certified conditions and verified to ≥99% purity by HPLC analysis, with endotoxin levels confirmed below 0.1 EU/mg. A full Certificate of Analysis (COA) is available upon request for research compliance and documentation purposes.
KPV is frequently studied in colitis models, intestinal epithelial cell-culture assays, and mucosal barrier integrity experiments. Research has demonstrated its ability to cross intestinal epithelium and interact directly with gut-associated lymphoid tissue (GALT), making it particularly relevant for inflammatory bowel disease and mucosal-healing studies. This compound is designated for research use only.
