$ 65 / 10mg
999 in stock (can be backordered)
5-Amino-1MQ (5-Amino-1-Methylquinolinium) is a small-molecule research compound that selectively inhibits nicotinamide N-methyltransferase (NNMT), an enzyme implicated in fat-cell metabolism, cellular energy regulation, and NAD+ salvage pathways. By blocking NNMT activity, 5-Amino-1MQ peptide has been shown in preclinical studies to increase intracellular NAD+ levels, promote adipocyte lipolysis, and reduce lipid accumulation.
NNMT catalyzes the methylation of nicotinamide, diverting it from the NAD+ biosynthesis pathway. 5-Amino-1MQ inhibits this enzyme, allowing more nicotinamide to be recycled into NAD+ — a critical coenzyme for mitochondrial function and energy metabolism. Researchers studying metabolic dysfunction and cellular energy balance frequently pair this compound with NAD+ supplementation models to investigate synergistic effects on the NAD+ salvage pathway.
Researchers investigating metabolic and energy pathways often study 5-Amino-1MQ alongside other compounds. MOTS-C targets mitochondrial-derived metabolic signaling, while AOD9604 focuses on GH-fragment-based fat metabolism — both complementary to NNMT inhibition research.
Each vial contains 5-Amino-1MQ peptide manufactured in the USA under ISO-certified conditions. Verified to ≥99% purity by HPLC analysis, with endotoxin levels screened below 0.1 EU/mg. Certificate of Analysis (COA) available upon request. For laboratory research use only.
5-Amino-1MQ compound should be stored at -20°C upon receipt to maintain its NNMT-inhibitory activity and chemical stability. Keep containers sealed and protected from light, heat, and moisture during storage. As a small-molecule quinolinium salt, 5-Amino-1MQ is typically more chemically stable than larger peptides, but proper cold storage is still essential for long-term preservation. If reconstitution is needed, use bacteriostatic water (0.9% benzyl alcohol) or an appropriate solvent as specified in the product documentation. Once in solution, store at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles and handle under standard aseptic laboratory conditions. For research use only.
5-Amino-1MQ emerged from research into NNMT inhibitors conducted at the University of Texas Medical Branch (UTMB) in Galveston, where investigators identified the NNMT enzyme as a key regulator of adipocyte metabolism and NAD+ homeostasis. The foundational 2018 study published in Biochemical Pharmacology demonstrated that selective NNMT inhibition increased intracellular SAM (S-adenosylmethionine) and NAD+ concentrations while reducing fat-cell size in vitro and in animal models. Subsequent research from UTMB, the University of Kentucky, and other academic centers has further characterized 5-Amino-1MQ’s effects on adipocyte lipolysis, energy expenditure, and metabolic syndrome pathways. The compound has been cited in over 40 peer-reviewed publications and continues to attract attention as a novel approach to metabolic research distinct from traditional receptor-agonist strategies. All references pertain to laboratory and preclinical research contexts only.
NNMT normally methylates nicotinamide, diverting it away from the NAD+ salvage pathway and reducing intracellular NAD+ availability. By inhibiting NNMT, 5-Amino-1MQ allows more nicotinamide to be recycled back into NAD+ through the salvage pathway, boosting this critical coenzyme for mitochondrial function and energy metabolism. This product is supplied for laboratory research use only.
Each vial is manufactured in the USA under ISO-certified conditions and verified to ≥99% purity by HPLC analysis, with endotoxin levels screened below 0.1 EU/mg. A Certificate of Analysis (COA) documenting purity, identity, and endotoxin data is available upon request for research compliance records.
Published preclinical studies have demonstrated that NNMT inhibition by 5-Amino-1MQ promotes adipocyte lipolysis, reduces lipid accumulation, and increases energy expenditure in cell-culture and animal models. These findings have positioned it as a leading research tool for studying the NNMT-NAD+ axis in obesity and metabolic syndrome contexts. This compound is designated for research use only.
