$ 49 / 10mg
999 in stock (can be backordered)
Melanotan II is a cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone (α-MSH) that activates multiple melanocortin receptor subtypes (MC1R through MC5R). This broad receptor profile makes Melanotan II peptide one of the most versatile melanocortin research tools available, studied for its effects on melanogenesis, appetite regulation, sexual-function signaling, and energy homeostasis in preclinical models.
Melanotan II peptide’s cyclic structure provides enhanced metabolic stability and receptor affinity compared to linear melanocortin analogues. It activates MC1R (melanogenesis), MC3R (energy homeostasis), MC4R (appetite regulation and sexual function), and MC5R (exocrine secretion). This multi-receptor activation produces a complex pharmacological profile that researchers use to study the interplay between pigmentation, metabolic signaling, and neuroendocrine pathways.
Melanotan I offers MC1R-selective melanogenesis for comparison studies. PT-141 (Bremelanotide) is derived from Melanotan II and targets MC4R specifically for sexual-function research. GHK-Cu provides complementary skin-biology research through copper-peptide mechanisms.
Each vial contains Melanotan II peptide manufactured in the USA under ISO-certified conditions. Verified to ≥99% purity by HPLC analysis, with endotoxin screening below 0.1 EU/mg. Certificate of Analysis (COA) available upon request. For laboratory research use only.
Lyophilized Melanotan II peptide should be stored at -20°C upon receipt to preserve stability and biological activity. Protect from light and moisture during storage. For reconstitution, use bacteriostatic water (0.9% benzyl alcohol) and allow the lyophilized powder to dissolve gently without vortexing. Once reconstituted, store the solution at 2–8°C (standard laboratory refrigerator) and use within 28 days to ensure peptide integrity. Avoid repeated freeze-thaw cycles, as this can degrade the cyclic structure and reduce receptor-binding affinity. All handling should follow standard aseptic laboratory techniques. For research use only.
Melanotan II was first synthesized in the early 1990s at the University of Arizona by researchers investigating melanocortin receptor pharmacology. The compound was designed as a cyclic analogue of α-MSH to improve metabolic stability and receptor potency over the linear parent hormone. Since its development, Melanotan II has been referenced in over 300 peer-reviewed publications spanning melanogenesis, appetite regulation, and sexual-function signaling. Key research institutions including the University of Arizona, the University of Florence, and Monash University have contributed foundational studies characterizing its multi-receptor binding profile. Melanotan II remains one of the most widely cited melanocortin agonists in preclinical pharmacology literature, with ongoing investigations into receptor subtype selectivity and downstream signaling cascades. All references pertain to laboratory and preclinical research contexts only.
Melanotan II is a broad melanocortin agonist that activates MC1R through MC5R, enabling researchers to study melanogenesis (MC1R), energy homeostasis (MC3R), appetite and sexual-function signaling (MC4R), and exocrine secretion (MC5R) within a single compound. This multi-receptor profile distinguishes it from selective agonists like PT-141 or Melanotan I. This product is supplied for laboratory research use only.
Melanotan II is manufactured in the USA under ISO-certified conditions and verified to ≥99% purity by HPLC analysis, with endotoxin screening confirmed below 0.1 EU/mg. A full Certificate of Analysis (COA) documenting purity, identity, and endotoxin levels is available upon request for research records.
Melanotan I is a linear peptide analogue with high selectivity for MC1R, making it primarily useful for melanogenesis studies, while Melanotan II is a cyclic peptide that activates multiple melanocortin receptor subtypes simultaneously. Researchers often use both compounds in comparative studies to isolate receptor-specific effects from the broader melanocortin signaling profile. Both products are intended for research use only.
