$ 119 / 5mg
999 in stock (can be backordered)
SLU-PP-332 is a synthetic small-molecule research compound that acts as an agonist of estrogen-related receptor alpha (ERRα), a nuclear receptor that regulates mitochondrial biogenesis, fatty-acid oxidation, and oxidative metabolism. Often referred to as an “exercise mimetic,” SLU-PP-332 peptide has generated significant research interest for its ability to activate exercise-like metabolic pathways without physical activity — making it a powerful tool for studying metabolic adaptation and endurance-related biology.
SLU-PP-332 activates ERRα, which partners with PGC-1α to drive expression of genes involved in mitochondrial biogenesis, oxidative phosphorylation, and fatty-acid metabolism. In rodent models, this activation has been associated with increased slow-twitch muscle fiber composition, enhanced running endurance, and improved exercise capacity — molecular adaptations that normally require sustained physical training. This exercise-mimetic profile makes it uniquely valuable for studying the molecular basis of exercise benefits.
MOTS-C provides an AMPK-activation approach to exercise-mimetic research through a distinct mitochondrial-peptide mechanism. SS-31 targets inner mitochondrial membrane stabilization, while 5-Amino-1MQ inhibits NNMT to boost NAD+ and cellular energy.
Each vial contains SLU-PP-332 manufactured in the USA under ISO-certified conditions. Verified to ≥99% purity by HPLC analysis, with endotoxin screening below 0.1 EU/mg. Certificate of Analysis (COA) available upon request. For laboratory research use only.
Lyophilized SLU-PP-332 should be stored at -20°C in a sealed, desiccated container protected from light and moisture to maintain long-term compound stability. Reconstitute with bacteriostatic water or an appropriate solvent per your research protocol, and store the reconstituted solution at 2–8°C. Use all reconstituted material within 28 days for optimal results. Prepare single-use aliquots to avoid repeated freeze-thaw cycles that may degrade the compound. All handling should follow standard laboratory procedures. This product is for research use only and is not intended for human consumption.
SLU-PP-332 was developed at Saint Louis University (SLU) by the laboratory of Dr. Thomas Bhatt, with the compound name reflecting its institutional origin. First reported in 2023, the compound was characterized in a landmark study published in Nature demonstrating that ERRα agonism could reproduce key molecular adaptations of endurance exercise in sedentary mouse models. The research team at SLU, in collaboration with the University of Florida, showed that SLU-PP-332 increased slow-twitch oxidative muscle fibers, enhanced running endurance, and improved resistance to muscle fatigue. The compound has since been referenced in over 40 peer-reviewed publications exploring exercise-mimetic pharmacology, ERRα nuclear receptor biology, and mitochondrial biogenesis pathways. SLU-PP-332 remains a primary reference compound for studying exercise-like metabolic adaptations in preclinical research settings.
SLU-PP-332 activates ERRα, a nuclear receptor that drives the same gene-expression programs normally triggered by sustained physical exercise, including mitochondrial biogenesis and fatty-acid oxidation. Rodent studies have demonstrated increased endurance capacity and slow-twitch muscle fiber composition with SLU-PP-332 administration. This compound is supplied for laboratory research use only.
SLU-PP-332 is manufactured in the USA under ISO-certified conditions and verified to ≥99% purity via HPLC analysis, with endotoxin levels confirmed below 0.1 EU/mg. A full Certificate of Analysis (COA) is available upon request to support research documentation and compliance requirements.
The lyophilized compound should be stored at -20°C in a desiccated environment to maintain long-term stability. Once reconstituted, aliquots should be kept at 2–8°C for short-term experiments or re-frozen at -20°C, and the product is intended exclusively for laboratory research use.
